NSC 57457

Name	Naphthohydroxamicacid
Synonyms	NSC 57457 Naphthohydroxamicacid a-Naphthohydroxamic acid 1-Naphthohydroxamic acid alpha-naphthohydroxamicacid HDAC Inhibitor XIX, Compound 2 N-hydroxynaphthalene-1-carboxamide Naphthalene-1-carbohydroximic acid N-Hydroxy-1-naphthalenecarboxamide N-HYDROXYNAPHTHALENE-1-CARBOXAMIDE
CAS	6953-61-3
InChI	InChI=1/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)

Risk Codes	52 - Harmful to aquatic organisms
WGK Germany	3
RTECS	QJ1894500

biological activity	1-naphthechoxamic acid (Compound 2) is a potent, selective HDAC8 inhibitor, the IC50 was 14 μm. 1-naphthydroxamic acid was more selective for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μm). 1-naphthydroxamic acid does not increase the acetylation of the overall histone H4 and does not reduce the activity of the total intracellular HDAC. 1-naphthechoxamic acid can induce tubulin acetylation.
Cell Line:	BE(2)-C, SK-N-BE(2) and SH-SY5Y cells
Concentration:	20 µM, 40 µM
Incubation Time:	0 hours, 24 hours, 48 hours, 72 hours, 96 hours, and 144 hours
Result:	Reduced cell numbers in a concentration-dependent manner. Dose-limiting toxicities (DLTs) included weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination.
Animal Model:	NMRI Foxn1 nude mice
Dosage:	0 mg/kg, 50 mg/kg, 100mg/kg, 200 mg/kg, 300 mg/kg 400 mg/kg
Administration:	Intraperitoneal injection; daily; for 10 days